ABSTRACT
Objective To investigate whether the complement system of COVID-19 is affected by vaccination, and also to explore the relationship between complement and length of stay in hospital, with a view to providing input for clinical diagnosis and the management of COVID-19 patients. Methods The patients admitted from November 1st to November 30th, 2021 in the Eighth Affiliated Hospital of Guangzhou Medical University were selected as subjects. According to the time of vaccination, the patients were divided into two groups as vaccinated within half a year and over half a year. Then C3, C4, IgG, IgM, IgA, COVID-19 IgG and IgM, neutral granulocyte and lymphocyte count were detected and all patients' hospitalized days were recorded. With their hospitalization days of 14 d as a threshold, the patients were divided into two groups, and the above indicators were compared. Results C3 concentration was (0.86±0.157) g/L in patients with vaccination within six months, which is significantly lower than (0.96±0.172) g/L in those over six months (P<0.05), but as for C4, IgG, IgM, IgA, COVID-19 IgG and IgM, neutral granulocyte and lymphocyte counts, there were no significant difference between two groups;as for the patients within 14 days of hospitalization, C3 and C4 concentrations were lower than those for more than 14 days, but the COVID-19 antibody IgG and IgM, lymphocyte counts were higher (all P<0.05). Conclusion Vaccination within half a year can make the body's immune function and complement system to identify viruses earlier, more beneficial to remove viruses, but this effect is weakened after half a year;when admission, C3, C4, COVID-19 IgG level and lymphocyte counts can be used to predict hospitalization time in COVID-19 patients. © 2022 by the Author(s).
ABSTRACT
Objective To analyze the clinical characteristics and antibody of 22 COVID-19 patients with the adsorbed SARS-CoV-2 vaccine innoculation, in order to benefit clinical prediction and treatment. Methods Totally 22 patients with COVID-19 after inactivated vaccination who were admitted to our hospital from December 2020 to March 2021 were selected as the research subjects. Demographic characteristic, clinical symptoms, blood tests, nucleic acids and antibody tests, chest CT and treatment methods were analyzed to figure out the clinical characteristics and antibody changes. Results The median age of 22 patients was 34.5 years old. The clinical symptoms were mainly cough (8 cases), expectoration (3 cases), poor appetite (3 cases), fever (1 case), chest tightness (1 case), throat discomfort(1 case) and nasal congestion and runny nose (1 case). The chest CT mainly showed unilateral pneumonia (2 cases) and bilateral pneumonia (7 cases), presenting as ground glass shadow (5 cases) or ground glass with patch shadow (4 cases). One patient's antibody turned out to be IgM(+)IgG(-), three cases with IgM (-)IgG(-), four with IgM(-)IgG(+) and fourteen with IgM(+)IgG(+) on admission. Conclusion The majority of COVID-19 patients treated by our hospital after inoculation of inactivated SARS-CoV-2 vaccine (Vero cells) are young and middle-aged men, and the clinical classification is mainly common type patients. The clinical symptoms are mainly cough, sputum, fever, throat discomfort, etc., and the chest imaging can show unilateral or bilateral ground glass shadow or patch shadow exudation lesions. The prognosis was good with all patients cured by routine treatment such as oxygen therapy and traditional Chinese medicine. After inoculating inactivated Vero cells, the patients infected with COVID-19 can rapidly produce a large number of IgG antibodies in a short time. © 2021 Editorial Office of Chinese Journal of Schistosomiasis Control. All right reserved.